Frequently Asked Questions

About Albumin


Q: Are there any animal derived materials used in our products?

With the exception of our lip balm which contains lanolin, an essential oil (which imparts a water-proofing function) derived from wool,  there are no animal or human derived materials used in the production or formulation of any of the remaining products.  The highly purified human albumin ingredient is a recombinant protein produced by biotechnology methods.

 

Q: Is albumin associated with any allergies?

 Albumin itself is not an allergen, its is a completely natural highly abundant protein in your body.  However, pet albumin or certain derivatives of albumin, can create allergic reactions:

  • Most allergic reactions to pets are actually to the pet's albumin, which has a very different amino acid sequence compared with the human sequence.  The allergic reaction is usually to the pet's albumin in the dander (minute skin flakes) - an interesting daily example of the significant role and presence of albumin in the skin.
  • The allergic reaction to nickel jewelry is actually not to nickel, but to the complex of nickel with your body's albumin, a protective reaction which requires the first amino acid of albumin.  This amino acid is eliminated in AlbagenTM along with the risk for this reaction which occurs in more than 7% of the population.
  • The allergic reaction to penicillin in some individuals is produced by the covalent attachment of penicillin to serum albumin in the blood stream, which is then recognized by the immune system in those individuals who have this allergy.

 

Q: What are the clinical uses of albumin-based skin care?

Our albumin-based products can be used for the protection, restoration and general skin health & maintenance to promote healing and to keep your skin looking its best - now and in the future.  Several clinical support applications are under evaluation to help patients manage a variety of skin conditions.  Please contact your physician for the suitability of these products regarding your personal use in any clinical support applications. 

 

Q: What is Albumin?

Albumin is the principal protein of the circulatory system and is chiefly responsible for the maintenance of colloid osmotic blood pressure (80%), blood pH and the transport and distribution of a plethora of endogenous and exogenous ligands. This unusually prolific binding capability forms the basis for albumin's unique protective function.  It is a large, highly stable protein, comprised of 585 amino acids.  Its half-life in the circulatory system is approximately 18 days.

Pharmaceutically, it is used as an excipient for vaccines and other biological therapeutics, but its main use has been as a volume expander since the pioneering work of Dr. Cohn at Harvard University during World War II.   

Historically, because of albumins abundance, low cost and high purity, it has been used in a variety of research applications, making it historically one of the most highly studied and applied proteins in biochemistry.  In addition to the use as a volume expander, some of the many applications include excipients (for vaccines and other biologics), cell culture, in vitro fertilization, medical device coatings, biomaterials and diagnostics.

In recent years, recombinant albumin made from yeast or other expression systems has become more widely available.  These products are generally by their nature free from risk from animal derived pathogens.

 



About Our Skin Care Products


Q: What is Albagen?

AlbagenTM is a patented hypoallergenic human serum albumin produced recombinantly by biotechnology methods.  Native human albumin is a large protein of 585 amino acids in length, Albagen is comprised of 584 amino acids in the prototypical human sequence with the elimination of a single amino acid at the n-terminus which is involved in the allergic reaction to nickel.  AlbagenTM is high purity and completely animal free - there are no risks asscoiated with animal pathogens.

 

Q: What happens to albumin as we age?

Albumin levels in the body peak at about age 10, then decrease gradually until we are about the age of 21 where they remain level for the next 20 years.  After age 40 they begin a gradual decline. Albumin is produced by the liver, as we age the ability of our liver to produce albumin declines. Albumin levels are a function of many factors which include general health, nutrition, and liver function.

 

Q: Has albumin been used in cosmetics before?

Bovine serum albumin because of its early availability and low cost, has been included as a component in powdered makeup and to create surface films to cover wrinkles.  Albumins derived from animal blood are now objectionable based on the current knowledge of risk issues of blood borne pathogens.

The anti-aging, restorative, protective, and other applications pioneered by our company, in addition to being free from animal derived materials, are completely novel*


* US and Foreign Patents and Patents Pending.